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4-ACO-DMT, O-Acetylpsilocin is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
In the body, 4-AcO-DMT / psilacetin is thought to be deacetylated into psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven, however, and is based on reports that most users cannot tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.There are, however, claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin.
Buy 4-Aco-DMT online
Buy 4-Aco-DMT online Quality Drug Online is a synthetically produced psychoactive drug. Its has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies
4-ACO-DMT, O-Acetylpsilocin is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
4-ACO-DMT (also known as O-Acetylpsilocin, 4-Acetoxy-DMT, or Psilacetin) is a synthetically produced psychedelic tryptamine. It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT. The compound has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies. Since they are both believed to be prodrugs of psilocin. Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile and the three compounds can be said to feel indistinguishable from each other. This allows 4-AcO-DMT to function as a perfect substitute for psilocybin mushrooms.
44-ACO-DMT and several other esters of psilocin were originally patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler. Despite this fact, 4-AcO-DMT remains a psychedelic with a limited history of use. Prior to its release as a grey area compound on the online research chemical market.
4-ACO-DMT ‘s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
What is 4-Aco-DMT?
In the body, 4-AcO-DMT is thought to be deacetylated into psilocin during first pass metabolism and passes through the liver . This has not been formally proven and is based on reports that most users cannot tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects. There are, however, claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin. Some users report that it lasts slightly longer than psilocin while others report that it lasts for a shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by 4-AcO-DMT more closely resemble those produced by DMT. These differences could be possible if 4-AcO-DMT is active itself and not merely as a prodrug.
EFFECTS
03
Pharmacology
Like psilocybin (4-PO-DMT), 4-AcO-DMT is an ester of psilocin (4-HO-DMT). The difference between the two is that psilocybin is the O-phosphorylated form, which naturally occurs in mushrooms; 4-AcO-DMT, on the other hand, is the O-acetylated form, hence the name O-Acetylpsilocin. In other words, 4-AcO-DMT has the same basic structure as both psilocin and psilocybin, but with an acetoxy group bonded to its indole ring.
Receptor binding
Very little data exist on the receptor binding and metabolism of 4-AcO-DMT. Like psilocybin, it’s thought to be a prodrug of psilocin—in this case, deacetylated to psilocin during first-pass metabolism by the stomach and liver. With this in mind, we can assume that 4-AcO-DMT activates the 5-HT2A serotonin receptors, which is a similar mechanism of action as psilocybin and many other psychedelics.
However, some people have come to believe that 4-AcO-DMT may be more than just a prodrug of psilocin. There are many anecdotal reports of people injecting or smoking 4-AcO-DMT and experiencing nearly immediate psychoactivity (i.e. when bypassing first-pass metabolism). This suggests it may have its own pharmacodynamic profile and could account for some of the differences between the psilocybin and 4-AcO-DMT experiences. That said, it’s worth noting that naturally occurring psilocybin tends to be accompanied by other alkaloids that have their own effects, such as baeocystin and norbaeocystin—neither of which are present in 4-AcO-DMT powders.
Safety and toxicity (Buy 4-Aco-DMT online)
Taking into account the pharmacological similarities, we can assume that it is just as safe and non-addictive as psilocybin/psilocin. Although clinical research is lacking—especially into its long-term effects and toxic overdose (if any)—anecdotal reports support its presumed safety. However, a number of 4-AcO-DMT trip reports report that very high doses can cause blackouts, vomiting, heart problems, hypertension, and seizures. No fatalities have been reported—at least in the absence of other drugs. 4 aco dmt
Dosage
It is usually sold as a fumarate salt (a white-ish powder) containing on average 1 mg of pure 4-AcO-DMT for every 1.24 mg of powder. If it’s a hydrochloride salt, it will contain on average 1 mg of pure 4-AcO-DMT for every 1.15 mg of powder. In practice, the difference may be negligible, but it’s worth knowing. Given the prevalence of 4-AcO-DMT fumarate—and the fact that it contains less of the active indole alkaloid—it’s safe to assume dosage guidelines found online refer to the fumarate salt. 4 aco dmt dosage
As a powder, it is usually taken orally, but it can also be taken intranasally (snorted/insufflated). For other methods see FAQ. Either way, it’s processed more rapidly by the body than psilocybin mushrooms, typically resulting in a faster, more intense onset. 4 aco dmt UK
Even high-end doses are tiny, as with DMT, so you’ll need a digital milligram scale to weigh out your desired amount, based on the following ranges: 4 aco dmt microdose
| Weight | 4 gram, 10 gram, 20 gram |
|---|
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